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and for those tesamorelin-treated patients completing the 26-week treatment period that were re-randomized to tesamorelin (T-T group) or re-randomized to placebo, 48.9% and 50.6%, respectively, had impaired glucose tolerance, while 4.3% re-randomized to tesamorelin and 12.9% re-randomized to placebo had diet-controlled diabetes mellitus

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The collagen synthesis mechanisms involve MAPK/ERK pathway activation, which upregulates collagen gene expression at the genetic level

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