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Second, many clinical trials are of relatively short duration (often 6 months), failing to capture the long-term efficacy and sustainability of interventions on OA progression, a inherently chronic disease

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Firstly, CCK-8 assay confirmed that 24-hour metformin treatment at concentrations of 0, 10, 25, and 50 M did not significantly affect chondrocyte viability (Fig

In addition, decreased survival of human lung cancer cells is associated with increased IGFBP-3 expression

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