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Jiang C, Chen M, Wu Y, et al

Furthermore, NADPH is replenished by the isocitrate dehydrogenase (IDH1/IDH2) branch of the citric acid cycle (TCA cycle), malic enzyme (ME1), and one-carbon metabolism (such as the folate cycle) depending on cell type or nutritional status

28.3) 5 , 6 After 2 to 4 days of primaquine ingestion, all the signs, symptoms, and laboratory results characteristic of an acute hemolytic episode are observed

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