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In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state
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SCHEME 1 Oxidative stress in epilepsy The brain is particularly susceptible to oxidative damage due to its high metabolic demand and per weight rate of oxygen consumption
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