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In contrast, ATF4 mainly drives CHAC1 transcription under stress conditions through its interaction with both the ATF/CRE and ACM motif ( In addition to ATF4, CHOP plays a critical role in regulating CHAC1 during UFR ( CHAC1 promoter
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For example, glucose is the main substrate that photoreceptors utilize to create ATP in vivo 12 , but they can oxidize lipids, lactate, and use amino acids, fatty acids (such as palmitate) and other intermediate substrates to produce ATP, especially under glucose-deprived conditions 10,11,12