You may feel a tingling sensation, this is a common effect in this type of product (caused by Vanillyl Butyl Ether )
The recombinant human GLP-1(7-36) [RhGLP-1 (7-36)], a biosynthetic agent belonging to the GLP-1 RAs, is also applied to treat T2DM clinically
This approach helps reduce nausea, especially during the first 4-5 weeks of treatment or after any dose adjustments
The body produces it by itself and we also get it from the diet, especially from meat and other animal-based foods
The main endogenous ligand for GLP-1R, the 29 amino acid peptide GLP-1(7-36)NH 2 , is highly susceptible to degradation by proteolytic enzymes that rapidly destroy it in the circulation, making it unsuitable as a therapeutic agent (Deacon et al., 1998)