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b) One of the most significant findings was that oral ingestion of ME-3 resulted in a substantial improvement in the systemic ratio of reduced (active) glutathione to oxidized (inactive) glutathione, which indicates a significant improvement in antioxidant protection throughout the entire body

Therefore, ablating the MPC should mimic the effects of etomoxir treatment since both ultimately result in diminished acetyl-CoA availability for oxidation in the TCA cycle

Minor concerns include some redness or irritation where the injection was delivered, which may last for a few hours at most

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