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Approximately 3000 PGCs per sample were transferred into 1.5-mL tubes and resuspended in 60 L of wash buffer (20 mM HEPES-KOH, pH 7.5, 150 mM NaCl, 0.5 mM spermidine, and protease inhibitors)

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In this regard, most studies look at berberines effects on nonalcoholic fatty liver disease, but inflammation is also a critical part of conditions like heart disease and diabetes.12 17 Notably, a 2020 meta-analysis found significant reductions in CRP (C-reactive protein, a major marker of inflammation) in patients taking berberine.18 A 2024 review of randomized controlled trials corroborated the findings of the 2020 meta-analysis.53 For diabetes care One of the few things we can almost conclusively say berberine supports is diabetic care