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From the perspective of the clinical care of T2D patients who require intensified injection therapy, our findings are consistent with existing treatment guidelines [1, 3] and a real-world study [47], showing that using a GLP-1RA versus insulin therapy has therapeutic benefits in terms of reduced risks of hypoglycemia and all-cause death
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The presence of GLP-1R in the phylogenetically oldest parts of the brain but not in the cortex emphasizes that GLP-1 is involved in the regulation of vital functions like feeding and satiety (141)
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