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Seek medical advice if you experience: Severe or persistent heartburn that does not respond to lifestyle changes and over-the-counter antacids within 2 weeks Difficulty or pain when swallowing (dysphagia or odynophagia), which may indicate oesophageal inflammation or stricture Unexplained weight loss beyond expected Wegovy effects, or loss of appetite accompanied by reflux symptoms Persistent nausea and vomiting that prevents adequate nutrition or hydration Vomiting blood (haematemesis) or passing black, tarry stools (melaena), which may indicate gastrointestinal bleeding these require same-day urgent assessment Severe chest pain , particularly if different from typical heartburn call 999 immediately to exclude cardiac causes Symptoms of anaemia such as fatigue, pallor, or breathlessness, which might suggest chronic gastrointestinal blood loss Red flag symptoms such as dysphagia, unexplained weight loss, gastrointestinal bleeding, or persistent vomiting warrant urgent referral for upper gastrointestinal endoscopy to exclude serious pathology including Barrett's oesophagus, peptic ulceration, or malignancy

0 0 Overweight and obesity pose a major global health challenge, with prevalence increasing steadily worldwide over recent decades

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Moreover, five days of T3 treatment resulted in an improvement of glucose tolerance in MMI mice (Fig