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Obesity itself can produce OS through several different pathways, including disrupting energy metabolism, interfering with endocrine homeostasis, inducing systemic chronic inflammatory responses and changing gut microbiota

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Homeyer, N., Horn, A

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3.2 MAPKAPK2 overexpression mitigates H2O2-triggered cellular toxicity as well as restores melanogenic capacity within melanocytes affected by vitiligo To evaluate the cytoprotective function of MAPKAPK2 under oxidative insult conditions, PIG3V cells were exposed to H 2 O 2 and transfected with either an empty vector or MAPKAPK2-expressing plasmid