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Molecular hydrogen exerts anti-inflammatory effects by regulating cytokines and inflammatory mediators in circulation and tissue, such as IL-1, IL-6, IL-10, TNF-, inducible NOS (iNOS), interferon- (INF), and vascular endothelial growth factor (VEGF), reducing the infiltration of macrophages and neutrophils in liver lesion tissues [8, 13, 35].After the body's inflammatory response is triggered, sensors on the surface of immune cells recognize and bind to these inflammatory inducers, inducing cascade transduction of a variety of classical inflammatory signaling pathways, including NF-B, MAPK, STAT3, etc

doi: 10.1016/j.bbadis.2024.167645 52 LiGLiuCYangLFengLZhangSAnJet al

Neurosci Biobehav Rev 129:117

Both reasons are valid but the approach, expectations, and oversight should differ accordingly

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