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The ANN model demonstrated a high degree of accuracy with a mean absolute relative deviation percentage of 3.207% and a coefficient of determination (R 2 ) of 0.993 for predicting solubility in different solvent systems

However, patients experiencing significant weight loss on GLP-1 therapy may require more frequent monitoring, with TSH rechecked 6-8 weeks after significant weight change or dose adjustment, then every 3-4 months during active weight loss