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Most of the mutations in SLC22A5 are missenses mutations but nonsense, splice site, and deletion/insertion mutations have also been identified
Anaphylaxis typically develops within minutes to hours of drug administration and constitutes a medical emergency
Interaction with Toll-like receptors leads to the activation of NF-B, resulting in the activation of the expression of pro-inflammatory cytokines and iNOS (Zheng et al., 2008
The causes are varied: heredity, hormonal fluctuations, stress, an unbalanced diet or skin ageing
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