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B.KolencD.AralicaG.MisicM.et al (2014)

Lentinan, -glucan from shiitake ( Lentinula edodes ): a review on structure, conformational transition, and gastro-intestinal interaction contributing towards its anti-diabetic potential

This non-overlap is directly relevant to the question of combination use, which is addressed later

Chronic mitochondrial ROS production in HF further drives myocyte apoptosis via ROS-mediated activation of caspases and mPTP opening, fibrosis through ROS-activated TGF- signaling in fibroblasts, and electrical instability due to oxidative damage to ion channels, increasing arrhythmia risk