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The Oxidized Form (GSSG) Once the reduced glutathione has given away its electron, it becomes oxidized
In vitro experiments demonstrated that agrin treatment significantly downregulated PDGFR and claudin-5 expression in a blood-brain barrier co-culture model comprising human brain microvascular endothelial cells and pericytes, suggesting that agrin may induce pericyte death and impair the integrity of the blood-brain barrier
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In addition, glutathione plays an important role in the activation of immune system cells and the cellular regeneration process
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