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This gastrointestinal issue stems from semaglutide's mechanism as a GLP-1 receptor agonist, which slows gastric emptying to improve blood sugar control and promote satiety

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Factors That May Affect Appropriateness According to general clinical guidance referenced in published sources, growth hormone secretagogues may not be appropriate for individuals with certain contraindications including active malignancies, uncontrolled diabetes, or other conditions that a clinician would evaluate during the prescribing process

Anybody who already has diabetes or pre-diabetic and is obese, people who have an elevated cardiac risk factor and are diabetic, those scores can be calculated by your primary care provider or cardiologist