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In an unprecedented move, the Trump administration issued an Addendum to the OPM Call Letter on January 31, 2025 stating that OPM no longer require[s] Plan Year 2026 proposals to clarify or update the obesity management benefit to include the elements listed in the bullets starting on the bottom of page 10 and continuing through the bottom of page 12 of Carrier Letter 2025-01. In other words, the evidence-based policy guidance to better manage the obesity benefit issued two weeks earlier no longer required carriers attention

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These pathological pathways are probably mediated, at least in part, through NLRP3 inflammasome stimulation and mitochondrial disruption

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Comparing mechanisms side by side The fundamental appeal of combining tesamorelin and retatrutide comes down to mechanism separation