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Insulin dose reduction of 20 to 50% at triple agonist initiation is consistent with the approach used in tirzepatide trials: the SURPASS-5 trial (N=475) reduced insulin glargine by 20% at tirzepatide initiation, which reduced hypoglycemia without sacrificing glycemic control
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If you have concerns about any aspect of your treatment, including skin changes, your healthcare team is there to provide guidance
This might involve creating a specific meal plan for the first few weeks, mapping out a gentle exercise routine, or establishing a schedule for your injection and meals
Serious events of acute cholecystitis were reported in 0.5% and 0.3% of patients on Trulicity and placebo respectively
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