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The published trials excluded several populations and conditions
They reported significantly increased P450 aromatase (CYP19A1) expression in endometriosis patients: 32.4% of the endometriosis patients presented moderate expression, and 67.6% presented strong expression, with no cases of negative or weak expression observed
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Following multiple doses, mean insulin-like growth factor (IGF-1) levels remained above baseline for up to 28 days
This may represent a normal part of follicle cycling acceleration rather than a true adverse effect
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