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2023) and is widely recognized as a multifactorial disorder resulting from complex interactions between genetic and environmental factors (Lord et al

Me-THF functions as one-carbon donor, supporting the methylation reaction of uridine monophosphate (UMP) to generate thymidine monophosphate (TMP)

This paradoxical reaction is not fully understood but is thought to be related to individual metabolic responses

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This is important as ERKs enhance tyrosine hydroxylase activity through phosphorylation after chronic morphine or cocaine use (Berhow et al., 1996)