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Mitochondria are highly dynamic organelles, that continually fuse and divide, and the balance between fusion and fission determines the size, shape, number and function of these organelles ( Importantly, the fine-tuned regulation of mitophagy seems to be impaired in PD, which is not an odd observation, since this mechanism is regulated by parkin and by the serine/threonine protein phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1), and mutations on these proteins are known to be related with rare familial forms of PD
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Running out mid-cycle interrupts the physiological processes you are trying to support
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