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Older patients with depressive and anxiety disorders are susceptible to the age-related acute and chronic brain and physical illnesses, including metabolic, endocrine and neurobiological disorders,1 and are at high risk for cardiovascular, and cerebrovascular comorbidities.2 The significant heterogeneity in geriatric depression results in difficulties in both comparing research findings and identifying biomarkers to establish homogeneous subgroups for depression personalized therapy.3 Since oxidative stress is associated with depression,4 it is reasonable to search for such biomarkers among antioxidant systems, i.e

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Sies H, Masumoto H (1997) Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite