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the most common reported effects are mild, transient local reactions such as redness, itching, stinging, or dryness

For example, cigarette smoke exposure has been shown to reduce ovarian reserve in mice by inducing apoptosis (Xu et al., 2024

185 Pyruvate kinase deficiency has a protective effect against replication of the malarial parasite in human erythrocytes.13,58 This protective effect may be related to reduced ATP levels in PK-deficient red blood cells