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Exercise, depletion of antioxidants and antioxidant manipulation
Shields DWT, Roth SE, Brenner MJ
Metabolic flexibility is the ability of a cell to efficiently switch between burning carbohydrates and fats depending on nutrient availability and immediate energy demands without suffering oxidative damage
In parallel, AMPK activates ULK1 by phosphorylating it at Ser317 and Ser777, synergistically promoting both lipophagy and mitophagy, which accelerates lipid clearance and degradation of damaged organelles
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