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We have shown the difference between VRK2-WT cells and VRK2-KO cells in the sensitivity to GSH inhibition and noted that sensitive cells exhibited surged ROS levels following GSH inhibition (Fig

6 This suggests that glutathiones antioxidative properties can directly interfere with the viral life cycle, potentially reducing the severity and duration of cold sore outbreaks

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It is posited that any beneficial immunological impact is attributable to melatonin's action on high-affinity receptors (MT1 and MT2), which are present on immunocompetent cells