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Shaking the vial Shaking creates foam and air-liquid interfaces that can degrade peptide over a vial's multi-week life

Gallbladder disease : Semaglutide has been associated with an increased risk of gallstones and gallbladder inflammation

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Misuse included taking more or less than a prescribed dose, using for a longer period than prescribed, tampering with injection equipment, and sharing with other people, like family and friends, without a prescription

This may occur because growth hormone signaling can temporarily affect blood vessel dilation and circulation