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Given the stable HRs across the spectrum of frailty, these differences in number needed to treat between frail and non-frail people are primarily driven by the higher number of events among frail patients, which highlights the greater vulnerability of this population. Lower CV risk with SGLT2 inhibitors vs
Neither has a public clinical development timeline as of April 2026
Caloric targets may need reduction during plateau phase
We cant fully divorce side effects from effectiveness, McCoy says
& Davidson, B
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