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The STEP-4 trial (Rubino et al., JAMA , 2021) studied this directly: patients who reached goal weight on 2.4 mg were randomized to continue 2.4 mg vs switch to placebo
Its not tirzepatide is better, end of discussion. Its not theyre basically the same. Ive prescribed both semaglutide and tirzepatide to thousands of patients
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Karl and Spencer discuss the worry surrounding lean mass loss while using GLP-1 agonists
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