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Participants were randomized 1:1:1:1 to receive oral semaglutide 7 mg, oral semaglutide 14 mg, orforglipron 12 mg, or orforglipron 36 mg, with both agents titrated in a stepwise fashion and efficacy data summarized under both efficacy and treatmentregimen estimand
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The apparent absence of the bone mineral density preservation effect seen with liraglutide in MC4R -deficient patients, unlike in common obesity, underscores the need for vigilant bone health assessment and potential adjunctive interventions in this group
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