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Notably, certain commensals, like Clostridium cluster XIVa and segmented filamentous bacteria, have the ability to push the host immune system toward regulatory responses via regulatory Treg expansion and IL-10 production (Touchefeu et al., 2014)

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Erianin directly interacts with MEK1/2 and blocks the activation of MAPK signaling, thus effectively inhibiting the proliferation of pancreatic cancer cells and the characteristics of cancer stem cells, including suppression of sphere-forming capacity and the downregulation of key stemness markers, such as CD133, CD 44, sex determining region y-box 2 (SOX 2), and octamer-binding transcription factor 4 (OCT 4) (32)

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