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Increasing the number of intestinal endocrine L-cells According to the impairment of L-cells development in T2DM, a promising strategy for treating T2DM is to increase the number of L-cells in the intestine, thereby increasing the production of GLP-1

In the Phase 2 trial, the most commonly reported adverse events were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the side effect profile seen with other GLP-1-based therapies

Additionally, they suppress glucagon secretion, a hormone that raises blood glucose levels

C., Bae, Y

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