Mannino GC, Greco A, De Lorenzo C, Andreozzi F, Marini MA, Perticone F, Sesti G
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doi: 10.1002/dmrr.70081 Summary Keywords cardiomyopathy, diabetes, endothelium, HMGB1, inflammation, meta-analysis, rodent models, systematic review Citation Ranasinghe R, Mathai M and Zulli A (2026) Investigating the biomarkers of diabetic-cardiomyopathy with the high mobility group box-1 as a potential anti-inflammatory therapeutic target: Systematic Review and meta-analysis
An important advantage of this therapy is that it does not significantly increase hormones such as cortisol or prolactin, which are often associated with unwanted side effects
This non-toxic profile distinguishes it from many other biologically active compounds and supports its favorable safety record