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In preclinical models and early human pharmacology work, ipamorelin stimulates GH release from pituitary somatotrophs via GHS-R1a agonism while producing minimal secondary release of adrenocorticotropic hormone (ACTH), cortisol, or prolactin
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Perrenoud, D., Homberger, H.P., Auderset, P.C., Emmenegger, R., Frenk, E., Saurt, J.H
REDEFINE 1 -- CagriSema phase 3 (Aronne et al., 2025): CagriSema 2.4/2.4 mg produced 22.7% mean weight loss at 68 weeks vs 2.1% placebo
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