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GLP-1 RAs act by stimulating insulin secretion in a glucose-dependent manner, inhibiting glucagon release, and slowing gastric emptying, which together improve overall metabolic control and reduce appetite (Nathan et al

Even patients with A1C below 5.7% often see improvements in fasting insulin and glucosemarkers of insulin sensitivity that predict future diabetes risk

But it contributes to the overall picture, especially when combined with glycogen water release and dietary changes

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Ongoing support beyond injections Weight loss injections in the UK are most effective when combined with sustainable lifestyle changes