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A potent CysLT1 receptor antagonist, montelukast inhibits the activation of the NF-B pathway and secretion of IL-6 and IL-8 in FLS (165), next to reducing the disease incidence and its activity (166)
In terms of statistical analysis, various efficacy analyses were performed in all participants that went through the randomization process while safety analysis were used to assess all participants that underwent randomization and were also exposed to one experimental treatment dosage
Weeks 36: 1.0 mg total blend once weekly ~30 units (0.30 mL)
FDA makes the final call
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