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Glutathiones job is to act as a shield, neutralizing these molecules before they can cause cellular damage

The predicted transition states for HEDS catalysis suggest that GSSEtOH binds in two different orientations because it is a product and substrate (Fig

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Finally, knockdown of Gln transporters (SLC38A1 and SLC1A5) or pharmacological inhibition of SLC1A5 also significantly blocked cysteine starvation-mediated ferroptosis [85, 86]