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In lipopolysaccharide (LPS)-induced depressive rat models, curcumin pre-treatment reduced neuronal death in the hippocampal CA1 region, likely via the miR-146a-5p/ERK signaling pathway, and was associated with improved synaptic function ( Patients with myocardial infarction (MI) exhibit significantly increased risks of developing depression and anxiety disorders (Sun et al., 2021
Mechanism 2: Prevention of Thyroid Protein Oxidation & Autoantigen Formation Oxidative stress in the thyroid doesn't just damage cells - it chemically modifies thyroid proteins, particularly thyroglobulin (Tg) and thyroid peroxidase (TPO)
Am J Lifestyle Med
Reduced glutathione (GSH) and oxidized glutathione (GSSG) form an interconnected redox couple reflecting peroxide detoxification, thiol chemistry, and reducing capacity
On the one hand, the redundancy and genetic interaction of these core transcription factors reveal their dose-dependent regulatory mechanism and the core role in biofilm formation, providing a genetic basis for developing antifungal strategies targeting this network (Glazier et al., 2017)
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