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"There is generally no need to see a doctor unless you have some signs of abnormal bleeding or problems with wounds healing," said Michels

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p62 competes with NRF2 for binding to KEAP1, and this interaction induces a dependent autophagic degradation of KEAP1 and subsequent NRF2 stabilization and activation in both MEFs and HEK293 cells [198]

May decrease the absorption of oral vitamin C supplements, requiring dosage adjustments