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Robert Recker, a bone metabolism researcher at Creighton University whose work on bisphosphonate adherence has been cited in over 200 publications, has noted that "the single most modifiable predictor of bisphosphonate treatment failure is incorrect administration timing," a finding consistent with the adherence data in the POSSIBLE US observational study (N=over 15,000 osteoporosis patients)

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Hormonal disorders: Hormonal imbalances due to thyroid disorders, polycystic ovary syndrome, and insulin resistance can trigger melanin production