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Extracellular relay and paracrine propagation Although direct membrane contacts and ROS-triggered waves provide two compelling frameworks for ferroptotic spread, neither fully explains how ferroptosis extends across anatomically separated yet functionally coupled cells

However, during oxidative stress, specific cysteine residues on Keap1 undergo chemical modification, impairing its ability to bind Nrf2 effectively

doi: 10.1053/j.gastro.2020.02.020 19 DulaiPSSinghSPatelJSoniMProkopLJYounossiZet al

Maintaining intestinal barrier integrity is therefore essential to prevent LPS translocation and limit disease progression (39, 53)

Glutathione can have a skin-lightening effect because it is known to inhibit the enzyme tyrosinase, which is necessary for the production of melanin (pigment)