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Dose escalation identified dose-limiting toxicitiesprimarily thrombocytopenia and neutropeniawith the maximum tolerated dose established at 675 mg/m weekly

In addition, some studies have also found the role of GPX4 in neutrophil autophagy, which is also worth pondering whether there is a connection with ferroptosis

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Imbalanced fas and CD40 expression of Mantle cell lymphoma cells may be responsible for their survival advantage