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2.1.1 MSU crystal deposition and inflammatory activation The direct trigger of gout is the deposition of MSU crystals within joints and periarticular tissues
[5] GPX4 is a phospholipid hydroperoxidase that protects cells against membrane lipid peroxidation
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Intracellular Glu is produced from glutamine (Gln) catalyzed by glutaminase (GLS, with two different isomers GLS1 and GLS2) [29, 30]
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