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Haematological symptoms typically appear first and include fatigue, weakness, and pallor due to megaloblastic anaemiaa condition where the bone marrow produces abnormally large, immature red blood cells that function poorly
5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide using SAM as a methyl donor
The condition develops gradually, often over months or years, and is particularly common among older adults in the UK
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