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5-Amino-1MQ operates as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme central to regulating nicotinamide metabolism and intracellular NAD+ levels
Studies have shown that when NNMTi is combined with a lowcalorie diet, the rate of body weight loss in obese mice is significantly faster than in either singleintervention group, with more pronounced reduction of adipose tissue and greater improvement in insulin sensitivity and hepatic metabolism
Novel small molecule inhibitors of nicotinamide N-methyltransferase (NNMT)
Liu H, Liu D, Zhao X, Wright M, Guo H, Deng Y, Guo H