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Stephens et al
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As children with SMA may have a limited carnitine synthetic capacity due to significantly diminished skeletal muscle mass, and VPA is known to inhibit carnitine transport and deplete carnitine levels by binding to VPA metabolites, we elected to combine VPA therapy with sufficient supplemental carnitine to avoid concerns about a confounding effect of carnitine depletion
One randomized control trial evaluated the effects of 2% w/w GSSG lotion on skin elasticity and wrinkle reduction involving lateral canthal lines
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