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(2017) Cell Metabolism, 25(5):10751090 Everard A, Belzer C, Geurts L, et al

Advances in drug delivery systems, including liposomes and nanophytosomes, address low solubility, rapid metabolism, and limited blood brain barrier penetration, thereby improving central nervous system exposure and pharmacodynamic effects, which is essential for clinical translation of several phytochemicals (Moghaddam et al., 2023

After propensity-score matching, the two cohorts (504 in each cohort, mean age 46.1 years, 57.5% women, 26.4% black, 54.7% white, 6.7% Hispanic) were balanced (see Supplementary Table S2 in the Supplementary Appendix)

Patients with heart failure with reduced ejection fraction experienced a 35% reduction in major cardiovascular events (hazard ratio 0.65, 95% CI 0.49-0.87), while those with heart failure with preserved ejection fraction saw a 31% reduction (hazard ratio 0.69, 95% CI 0.51-0.91)

This can raise questions about what to expect