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On the other hand, it is beneficial to introduce advanced analytical techniques that accurately measure the changes of intracellular GSH/GSSG concentrations

As collagen levels naturally decline with age, skin may become thinner, less firm, and more prone to wrinkles

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We hope that adoption of the border instead of the barrier as a metaphor to describe bloodbrain and blood-CSF interfaces might stimulate new drug approaches to modulate the properties of CNS endothelial and epithelial layers or take advantage of endogenous systems rather than finding ways tobreak the barrier to facilitate drug delivery to the CNS

For example, triptans should be avoided (when possible) in patients who are at risk for cardiovascular events and stroke (i.e., patients with heart disease)