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The mean absolute bioavailability observed after IM injections was approximately 14%19% in rats and 45%51% in beagle dogs
Stuart, D.O., published by Quill Driver Books, 2011.
Still, they work through fundamentally different mechanisms: AOD-9604 is a modified fragment of human growth hormone designed to isolate its lipolytic (fat-metabolizing) region without triggering the broader GH/IGF-1 response, while Tesamorelin is a growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary to increase natural GH production
An interesting finding from the study was the rapid reduction in lameness observed in rabbits receiving the combination of AOD9604 and HA, with full recovery noted in approximately 11 days
When stimulated simultaneously, the two receptors produce a synergistic GH pulse that substantially exceeds what either compound generates alone an effect documented in the broader GHRH + GHRP literature going back to the 1990s
