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March 23, 2026 Key takeaways GLP-1 raises resting heart rate and lowers nighttime HRV
Monthly for the first three months during titration, then quarterly once you reach a stable maintenance dose
However, these findings in diabetes populations may not fully generalize to non-diabetic individuals using these medications solely for weight loss
Increase gut permeability (leaky gut) 10
Conclusion Small increases in resting heart rate with GLP-1 therapy are real but generally modest and clinically manageable
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